@article{dekker20174dn, author = {Dekker, Job and Belmont, Andrew S and Guttman, Mitchell and Leshyk, Victor O and Lis, John T and Lomvardas, Stavros and Mirny, Leonid A and O'Shea, Clodagh C and Park, Peter J and Ren, Bing and Politz, Joan C Ritland and Shendure, Jay and Zhong, Sheng and {the 4D Nucleome Network}}, title = {The 4D nucleome project}, journal = {Nature}, volume = {549}, number = {7671}, pages = {219--226}, year = {2017}, abstract = {The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.}, doi = {10.1038/nature23884} }