Visual Computing Group

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer E. Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, Li Ding, Edward D. Esplin, James M. Ford, Jeremy Goecks, Sharmistha Ghosh, Joe W. Gray, Justin Guinney, Sean E. Hanlon, Shannon K. Hughes, E. Shelley Hwang, Christine A. Iacobuzio-Donahue, Judit Jané-Valbuena, Bruce E. Johnson, Ken S. Lau, Tracy Lively, Sarah A. Mazzilli, Dana Pe’er, Sandro Santagata, Alex K. Shalek, Denis Schapiro, Michael P. Snyder, Peter K. Sorger, Avrum E. Spira, Sudhir Srivastava, Kai Tan, Robert B. West, Elizabeth H. Williams, Denise Aberle, Samuel I. Achilefu, Foluso O. Ademuyiwa, Andrew C. Adey, Rebecca L. Aft, Rachana Agarwal, Ruben A. Aguilar, Fatemeh Alikarami, Viola Allaj, Christopher Amos, Robert A. Anders, Michael R. Angelo, Kristen Anton, Orr Ashenberg, Jon C. Aster, Ozgun Babur, Amir Bahmani, Akshay Balsubramani, David Barrett, Jennifer Beane, Diane E. Bender, Kathrin Bernt, Lynne Berry, Courtney B. Betts, Julie Bletz, Katie Blise, Adrienne Boire, Genevieve Boland, Alexander Borowsky, Kristopher Bosse, Matthew Bott, Ed Boyden, James Brooks, Raphael Bueno, Erik A. Burlingame, Qiuyin Cai, Joshua Campbell, Wagma Caravan, Ethan Cerami, Hassan Chaib, Joseph M. Chan, Young Hwan Chang, Deyali Chatterjee, Ojasvi Chaudhary, Alyce A. Chen, Bob Chen, Changya Chen, Chia-hui Chen, Feng Chen, Yu-An Chen, Milan G. Chheda, Koei Chin, Roxanne Chiu, Shih-Kai Chu, Rodrigo Chuaqui, Jaeyoung Chun, Luis Cisneros, Robert J. Coffey, Graham A. Colditz, Kristina Cole, Natalie Collins, Kevin Contrepois, Lisa M. Coussens, Allison L. Creason, Daniel Crichton, Christina Curtis, Tanja Davidsen, Sherri R. Davies, Ino de Bruijn, Laura Dellostritto, Angelo De Marzo, Emek Demir, David G. DeNardo, Dinh Diep, Li Ding, Sharon Diskin, Xengie Doan, Julia Drewes, Stephen Dubinett, Michael Dyer, Jacklynn Egger, Jennifer Eng, Barbara Engelhardt, Graham Erwin, Edward D. Esplin, Laura Esserman, Alex Felmeister, Heidi S. Feiler, Ryan C. Fields, Stephen Fisher, Keith Flaherty, Jennifer Flournoy, James M. Ford, Angelo Fortunato, Allison Frangieh, Jennifer L. Frye, Robert S. Fulton, Danielle Galipeau, Siting Gan, Jianjiong Gao, Long Gao, Peng Gao, Vianne R. Gao, Tim Geiger, Ajit George, Gad Getz, Sharmistha Ghosh, Marios Giannakis, David L. Gibbs, William E. Gillanders, Jeremy Goecks, Simon P. Goedegebuure, Alanna Gould, Kate Gowers, Joe W. Gray, William Greenleaf, Jeremy Gresham, Jennifer L. Guerriero, Tuhin K. Guha, Alexander R. Guimaraes, Justin Guinney, David Gutman, Nir Hacohen, Sean Hanlon, Casey R. Hansen, Olivier Harismendy, Kathleen A. Harris, Aaron Hata, Akimasa Hayashi, Cody Heiser, Karla Helvie, John M. Herndon, Gilliam Hirst, Frank Hodi, Travis Hollmann, Aaron Horning, James J. Hsieh, Shannon Hughes, Won Jae Huh, Stephen Hunger, Shelley E. Hwang, Christine A. Iacobuzio-Donahue, Heba Ijaz, Benjamin Izar, Connor A. Jacobson, Samuel Janes, Judit Jané-Valbuena, Reyka G. Jayasinghe, Lihua Jiang, Brett E. Johnson, Bruce Johnson, Tao Ju, Humam Kadara, Klaus Kaestner, Jacob Kagan, Lukas Kalinke, Robert Keith, Aziz Khan, Warren Kibbe, Albert H. Kim, Erika Kim, Junhyong Kim, Annette Kolodzie, Mateusz Kopytra, Eran Kotler, Robert Krueger, Kostyantyn Krysan, Anshul Kundaje, Uri Ladabaum, Blue B. Lake, Huy Lam, Rozelle Laquindanum, Ken S. Lau, Ashley M. Laughney, Hayan Lee, Marc Lenburg, Carina Leonard, Ignaty Leshchiner, Rochelle Levy, Jerry Li, Christine G. Lian, Kian-Huat Lim, Jia-Ren Lin, Yiyun Lin, Qi Liu, Ruiyang Liu, Tracy Lively, William J.R. Longabaugh, Teri Longacre, Cynthia X. Ma, Mary Catherine Macedonia, Tyler Madison, Christopher A. Maher, Anirban Maitra, Netta Makinen, Danika Makowski, Carlo Maley, Zoltan Maliga, Diego Mallo, John Maris, Nick Markham, Jeffrey Marks, Daniel Martinez, Robert J. Mashl, Ignas Masilionais, Jennifer Mason, Joan Massagué, Pierre Massion, Marissa Mattar, Richard Mazurchuk, Linas Mazutis, Sarah A. Mazzilli, Eliot T. McKinley, Joshua F. McMichael, Daniel Merrick, Matthew Meyerson, Julia R. Miessner, Gordon B. Mills, Meredith Mills, Suman B. Mondal, Motomi Mori, Yuriko Mori, Elizabeth Moses, Yael Mosse, Jeremy L. Muhlich, George F. Murphy, Nicholas E. Navin, Tal Nawy, Michel Nederlof, Reid Ness, Stephanie Nevins, Milen Nikolov, Ajit Johnson Nirmal, Garry Nolan, Edward Novikov, Philipp Oberdoerffer, Brendan O’Connell, Michael Offin, Stephen T. Oh, Anastasiya Olson, Alex Ooms, Miguel Ossandon, Kouros Owzar, Swapnil Parmar, Tasleema Patel, Gary J. Patti, Dana Pe’er, Itsik Pe er, Tao Peng, Daniel Persson, Marvin Petty, Hanspeter Pfister, Kornelia Polyak, Kamyar Pourfarhangi, Sidharth V. Puram, Qi Qiu, Álvaro Quintanal-Villalonga, Arjun Raj, Marisol Ramirez-Solano, Rumana Rashid, Ashley N. Reeb, Aviv Regev, Mary Reid, Adam Resnick, Sheila M. Reynolds, Jessica L. Riesterer, Scott Rodig, Joseph T. Roland, Sonia Rosenfield, Asaf Rotem, Sudipta Roy, Orit Rozenblatt-Rosen, Charles M. Rudin, Marc D. Ryser, Sandro Santagata, Maria Santi-Vicini, Kazuhito Sato, Denis Schapiro, Deborah Schrag, Nikolaus Schultz, Cynthia L. Sears, Rosalie C. Sears, Subrata Sen, Triparna Sen, Alex Shalek, Jeff Sheng, Quanhu Sheng, Kooresh I. Shoghi, Martha J. Shrubsole, Yu Shyr, Alexander B. Sibley, Kiara Siex, Alan J. Simmons, Dinah S. Singer, Shamilene Sivagnanam, Michal Slyper, Michael P. Snyder, Artem Sokolov, Sheng-Kwei Song, Peter K. Sorger, Austin Southard-Smith, Avrum Spira, Sudhir Srivastava, Janet Stein, Phillip Storm, Elizabeth Stover, Siri H. Strand, Timothy Su, Damir Sudar, Ryan Sullivan, Lea Surrey, Mario Suvà, Kai Tan, Nadezhda V. Terekhanova, Luke Ternes, Lisa Thammavong, Guillaume Thibault, George V. Thomas, Vésteinn Thorsson, Ellen Todres, Linh Tran, Madison Tyler, Yasin Uzun, Anil Vachani, Eliezer Van Allen, Simon Vandekar, Deborah J. Veis, Sébastien Vigneau, Arastoo Vossough, Angela Waanders, Nikhil Wagle, Liang-Bo Wang, Michael C. Wendl, Robert West, Elizabeth H. Williams, Chi-yun Wu, Hao Wu, Hung-Yi Wu, Matthew A. Wyczalkowski, Yubin Xie, Xiaolu Yang, Clarence Yapp, Wenbao Yu, Yinyin Yuan, Dadong Zhang, Kun Zhang, Mianlei Zhang, Nancy Zhang, Yantian Zhang, Yanyan Zhao, Daniel Cui Zhou, Zilu Zhou, Houxiang Zhu, Qin Zhu, Xiangzhu Zhu, Yuankun Zhu, and Xiaowei Zhuang.

Cell, 2020.

Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and therapeutic resistance—involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types. This effort complements both ongoing efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a single point in time. Generating single-cell, multiparametric, longitudinal atlases and integrating them with clinical outcomes should help identify novel predictive biomarkers and features as well as therapeutically relevant cell types, cell states, and cellular interactions across transitions. The resulting tumor atlases should have a profound impact on our understanding of cancer biology and have the potential to improve cancer detection, prevention, and therapeutic discovery for better precision-medicine treatments of cancer patients and those at risk for cancer.

Citation

@article {rozenblatt-rosen2020the,
    title={The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution},
    author={Orit Rozenblatt-Rosen and Aviv Regev and Philipp Oberdoerffer and Tal Nawy and Anna Hupalowska and Jennifer E. Rood and Orr Ashenberg and Ethan Cerami and Robert J. Coffey and Emek Demir and Li Ding and Edward D. Esplin and James M. Ford and Jeremy Goecks and Sharmistha Ghosh and Joe W. Gray and Justin Guinney and Sean E. Hanlon and Shannon K. Hughes and E. Shelley Hwang and Christine A. Iacobuzio-Donahue and Judit Jané-Valbuena and Bruce E. Johnson and Ken S. Lau and Tracy Lively and Sarah A. Mazzilli and Dana Pe’er and Sandro Santagata and Alex K. Shalek and Denis Schapiro and Michael P. Snyder and Peter K. Sorger and Avrum E. Spira and Sudhir Srivastava and Kai Tan and Robert B. West and Elizabeth H. Williams and Denise Aberle and Samuel I. Achilefu and Foluso O. Ademuyiwa and Andrew C. Adey and Rebecca L. Aft and Rachana Agarwal and Ruben A. Aguilar and Fatemeh Alikarami and Viola Allaj and Christopher Amos and Robert A. Anders and Michael R. Angelo and Kristen Anton and Orr Ashenberg and Jon C. Aster and Ozgun Babur and Amir Bahmani and Akshay Balsubramani and David Barrett and Jennifer Beane and Diane E. Bender and Kathrin Bernt and Lynne Berry and Courtney B. Betts and Julie Bletz and Katie Blise and Adrienne Boire and Genevieve Boland and Alexander Borowsky and Kristopher Bosse and Matthew Bott and Ed Boyden and James Brooks and Raphael Bueno and Erik A. Burlingame and Qiuyin Cai and Joshua Campbell and Wagma Caravan and Ethan Cerami and Hassan Chaib and Joseph M. Chan and Young Hwan Chang and Deyali Chatterjee and Ojasvi Chaudhary and Alyce A. Chen and Bob Chen and Changya Chen and Chia-hui Chen and Feng Chen and Yu-An Chen and Milan G. Chheda and Koei Chin and Roxanne Chiu and Shih-Kai Chu and Rodrigo Chuaqui and Jaeyoung Chun and Luis Cisneros and Robert J. Coffey and Graham A. Colditz and Kristina Cole and Natalie Collins and Kevin Contrepois and Lisa M. Coussens and Allison L. Creason and Daniel Crichton and Christina Curtis and Tanja Davidsen and Sherri R. Davies and Ino de Bruijn and Laura Dellostritto and Angelo De Marzo and Emek Demir and David G. DeNardo and Dinh Diep and Li Ding and Sharon Diskin and Xengie Doan and Julia Drewes and Stephen Dubinett and Michael Dyer and Jacklynn Egger and Jennifer Eng and Barbara Engelhardt and Graham Erwin and Edward D. Esplin and Laura Esserman and Alex Felmeister and Heidi S. Feiler and Ryan C. Fields and Stephen Fisher and Keith Flaherty and Jennifer Flournoy and James M. Ford and Angelo Fortunato and Allison Frangieh and Jennifer L. Frye and Robert S. Fulton and Danielle Galipeau and Siting Gan and Jianjiong Gao and Long Gao and Peng Gao and Vianne R. Gao and Tim Geiger and Ajit George and Gad Getz and Sharmistha Ghosh and Marios Giannakis and David L. Gibbs and William E. Gillanders and Jeremy Goecks and Simon P. Goedegebuure and Alanna Gould and Kate Gowers and Joe W. Gray and William Greenleaf and Jeremy Gresham and Jennifer L. Guerriero and Tuhin K. Guha and Alexander R. Guimaraes and Justin Guinney and David Gutman and Nir Hacohen and Sean Hanlon and Casey R. Hansen and Olivier Harismendy and Kathleen A. Harris and Aaron Hata and Akimasa Hayashi and Cody Heiser and Karla Helvie and John M. Herndon and Gilliam Hirst and Frank Hodi and Travis Hollmann and Aaron Horning and James J. Hsieh and Shannon Hughes and Won Jae Huh and Stephen Hunger and Shelley E. Hwang and Christine A. Iacobuzio-Donahue and Heba Ijaz and Benjamin Izar and Connor A. Jacobson and Samuel Janes and Judit Jané-Valbuena and Reyka G. Jayasinghe and Lihua Jiang and Brett E. Johnson and Bruce Johnson and Tao Ju and Humam Kadara and Klaus Kaestner and Jacob Kagan and Lukas Kalinke and Robert Keith and Aziz Khan and Warren Kibbe and Albert H. Kim and Erika Kim and Junhyong Kim and Annette Kolodzie and Mateusz Kopytra and Eran Kotler and Robert Krueger and Kostyantyn Krysan and Anshul Kundaje and Uri Ladabaum and Blue B. Lake and Huy Lam and Rozelle Laquindanum and Ken S. Lau and Ashley M. Laughney and Hayan Lee and Marc Lenburg and Carina Leonard and Ignaty Leshchiner and Rochelle Levy and Jerry Li and Christine G. Lian and Kian-Huat Lim and Jia-Ren Lin and Yiyun Lin and Qi Liu and Ruiyang Liu and Tracy Lively and William J.R. Longabaugh and Teri Longacre and Cynthia X. Ma and Mary Catherine Macedonia and Tyler Madison and Christopher A. Maher and Anirban Maitra and Netta Makinen and Danika Makowski and Carlo Maley and Zoltan Maliga and Diego Mallo and John Maris and Nick Markham and Jeffrey Marks and Daniel Martinez and Robert J. Mashl and Ignas Masilionais and Jennifer Mason and Joan Massagué and Pierre Massion and Marissa Mattar and Richard Mazurchuk and Linas Mazutis and Sarah A. Mazzilli and Eliot T. McKinley and Joshua F. McMichael and Daniel Merrick and Matthew Meyerson and Julia R. Miessner and Gordon B. Mills and Meredith Mills and Suman B. Mondal and Motomi Mori and Yuriko Mori and Elizabeth Moses and Yael Mosse and Jeremy L. Muhlich and George F. Murphy and Nicholas E. Navin and Tal Nawy and Michel Nederlof and Reid Ness and Stephanie Nevins and Milen Nikolov and Ajit Johnson Nirmal and Garry Nolan and Edward Novikov and Philipp Oberdoerffer and Brendan O’Connell and Michael Offin and Stephen T. Oh and Anastasiya Olson and Alex Ooms and Miguel Ossandon and Kouros Owzar and Swapnil Parmar and Tasleema Patel and Gary J. Patti and Dana Pe’er and Itsik Pe er and Tao Peng and Daniel Persson and Marvin Petty and Hanspeter Pfister and Kornelia Polyak and Kamyar Pourfarhangi and Sidharth V. Puram and Qi Qiu and Álvaro Quintanal-Villalonga and Arjun Raj and Marisol Ramirez-Solano and Rumana Rashid and Ashley N. Reeb and Aviv Regev and Mary Reid and Adam Resnick and Sheila M. Reynolds and Jessica L. Riesterer and Scott Rodig and Joseph T. Roland and Sonia Rosenfield and Asaf Rotem and Sudipta Roy and Orit Rozenblatt-Rosen and Charles M. Rudin and Marc D. Ryser and Sandro Santagata and Maria Santi-Vicini and Kazuhito Sato and Denis Schapiro and Deborah Schrag and Nikolaus Schultz and Cynthia L. Sears and Rosalie C. Sears and Subrata Sen and Triparna Sen and Alex Shalek and Jeff Sheng and Quanhu Sheng and Kooresh I. Shoghi and Martha J. Shrubsole and Yu Shyr and Alexander B. Sibley and Kiara Siex and Alan J. Simmons and Dinah S. Singer and Shamilene Sivagnanam and Michal Slyper and Michael P. Snyder and Artem Sokolov and Sheng-Kwei Song and Peter K. Sorger and Austin Southard-Smith and Avrum Spira and Sudhir Srivastava and Janet Stein and Phillip Storm and Elizabeth Stover and Siri H. Strand and Timothy Su and Damir Sudar and Ryan Sullivan and Lea Surrey and Mario Suvà and Kai Tan and Nadezhda V. Terekhanova and Luke Ternes and Lisa Thammavong and Guillaume Thibault and George V. Thomas and Vésteinn Thorsson and Ellen Todres and Linh Tran and Madison Tyler and Yasin Uzun and Anil Vachani and Eliezer Van Allen and Simon Vandekar and Deborah J. Veis and Sébastien Vigneau and Arastoo Vossough and Angela Waanders and Nikhil Wagle and Liang-Bo Wang and Michael C. Wendl and Robert West and Elizabeth H. Williams and Chi-yun Wu and Hao Wu and Hung-Yi Wu and Matthew A. Wyczalkowski and Yubin Xie and Xiaolu Yang and Clarence Yapp and Wenbao Yu and Yinyin Yuan and Dadong Zhang and Kun Zhang and Mianlei Zhang and Nancy Zhang and Yantian Zhang and Yanyan Zhao and Daniel Cui Zhou and Zilu Zhou and Houxiang Zhu and Qin Zhu and Xiangzhu Zhu and Yuankun Zhu and Xiaowei Zhuang},
    journal={Cell},
    volume={181},
    number={2},
    pages={236--249},
    year={2020},
    issn={0092-8674},
    doi={https://doi.org/10.1016/j.cell.2020.03.053},
    url={https://www.sciencedirect.com/science/article/pii/S0092867420303469},
    keywords={Cancer Moonshot, Human Tumor Atlas, pre-cancer, tumor, resistance, metastasis, cancer transitions, single-cell genomics, spatial genomics, spatial imaging, data integration, AI, data visualization}
}

BibTex

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

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